Possible causes of the first case of pericarditis include: Viruses, such as herpes, influenza, adenovirus, enterovirus or Epstein-Barr Autoimmune conditions, such as lupus, scleroderma and rheumatoid arthritis Complications from a heart attack or heart surgery Health problems, such as kidney failure or cancer Bacterial, fungal and parasitic infections (most common in people with compromised immune systems) Radiation to the chest Chest trauma Certain medications, such as some anti-seizure medications, anticoagulants, antiarrhythmics and newer cancer therapies If a pericarditis flare happens again, its often because the first flare wasnt fully resolved or because the body has had an autoinflammatory response
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