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While the study did not assess the levels of urine cotinine or carboxyhemoglobin, we selected CO as a biological marker because it is simple and quick to measure, less expensive than a battery of laboratory tests, and noninvasive, making it more agreeable to the subjects as reported by Middleton et al

Since moxibustion can leave permanent scarring, this cultural practice may not be considered acceptable to cultures that do not consider the treatment beneficial

These substances interfere with normal cellular processes needed for healing: namely fibroblast activity, collagen formation, tissue regeneration

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