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The guidelines also state that enterprises should contribute to the effective abolition of child labor and take adequate steps to ensure occupational health and safety in their operations.[244] The OECD and the Food and Agriculture Organization of the United Nations (FAO) have developed a five-step framework for human rights due diligence in agricultural supply chains: 1) establish strong management systems

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[21] Misuse of nicotine replacement therapies (NRTs) , such as overusing patches, gums, or lozenges, can also lead to excessive nicotine exposure

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