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Following a single dose in humans, peak plasma concentrations of hydroxybupropion occur approximately 3 hours after administration of bupropion hydrochloride tablets and are approximately 10 times the peak level of the parent drug at steady state

19 Commonly reported oral symptoms include xerostomia, burning, pain, oral ulceration, nicotine stomatitis, hairy tongue and angular cheilitis Poor-quality evidence exists with regard to oral symptoms pertaining to ENDS, usually because the data are self-reported

Nationally, more than 8 of every 10 youth, aged 12-17 years who use e-cigarettes said they use flavored e-cigarettes