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Funding This investigator initiated study was sponsored by ECLAT srl, a spin-off of the University of Catania, with the help of a grant from the Foundation for a Smoke-Free World Inc., a US nonprofit 501(c)(3) private foundation with a mission to end smoking in this generation

The nicotine is absorbed into the bloodstream through the mucous membrane of your gum and mouth, providing an intense, long-lasting buzz

These differences have important implications for intervention design and implementation in LMICs

This may result in reduced interactions with public health messaging and limited awareness of the increased exposure to hazardous and potentially harmful chemicals that may occur with different forms of tobacco products