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Criteria for Determining the Most Addictive Drug To determine which substance holds the title of most addictive drug, its essential to consider several criteria, each playing a crucial role in shaping a drugs addictive potential: Dependence Potential: Some drugs are more likely to lead to physical or psychological dependence than others

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We know from decades of experience and data that people will find their way to unregulated markets and this will actually increase their exposure to harmboth in terms of questionable product and retail environments, he said