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Tobacco regulation is a huge part of reaching the goals hes outlined for reducing chronic disease and a really important part of the conversation we need to have in this country, said Chrissie Juliano of the Big Cities Health Coalition, which represents the heads of more than 30 metropolitan health departments
While many theoretically restrict entry to adults 21+, that often is not well enforced
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But, whereas the acute effects of nicotine in the VTA predominantly affect GABA neurons, the nAChRs in these cells desensitize rapidly, leading to a long-lasting excitation of the DA neurons through removal of their inhibition
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![Cigarette advertisement conspicuously pasted on wall. Source: [1]. Big](https://www.researchgate.net/publication/340072688/figure/fig4/AS:871523002896386@1584798684508/Cigarette-advertisement-conspicuously-pasted-on-wall-Source-1-Big-Tobacco-Tiny.png)
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