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Epigenomes change throughout our lives and can be affected by a variety of genetic or nongenetic factors including aging, our lifestyles, exposure to hormones, chemicals, and environmental factors, and even stress and psychological trauma

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Furthermore, MMPs contribute to CVDs and cancers by degenerating extracellular matrix and mediating inflammation through post-translational processing of inflammatory cytokines, chemokines, cell adhesion molecules, and their receptors on cells [18, 42]