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This adaptation creates tolerance, requiring increased nicotine intake to achieve the same effects

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"The Evolution of Smoking and Intoxicant Plant Use in Ancient Northwestern North America." American Antiquity 86.4 (2021): 715-733

In a 2012 review conducted in LMICs, only three of the included interventions incorporated social influence components, and the evidence was inconclusive for whether they were effective in reducing smoking uptake and progression to regular smoking (Munabi-Babigumira et al., 2012)