Kyphoscoliosis Types Major Criteria Severe joint laxity with recurrent dislocations in many joints Congenital, bilateral hip dislocation Inheritance Autosomal dominant Arthrochalasia Type (VIIA/B) Etiology Mutations in either COL1A1 or COL1A2 that interfere with amino-terminal propeptide cleavage of proa1(I) or proa2(I) chains respectively Arthrochalasia Type Major Criteria Severe skin fragility Sagging, redundant skin (not hyperextensible) Inheritance Autosomal recessive Dermatosporaxis Type (VIIC) Etiology Homozygous mutations in Type I collagen amino-peptidase and deficiency of the enzyme
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