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Accessed Jan 2019 Acknowledgements The authors thank Celerion who conducted the study and analysed the data

Thus, this group can be used to test potential bias due to pleiotropy (that the gene affects more than one exposure) in Mendelian randomisation analyses.38 We did observe some evidence for an association between the variant and anxiety in never smokers, a finding previously reported by the HUNT study.40 Removal of HUNT from this analysis did not affect the point estimate, suggesting that this association is not driven solely by the data from this study (see online supplementary figure S6)

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