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Mutations in the GTPases optic atrophy 1 (OPA1) and Mfn2 are associated with autosomal dominant optic atrophy and Charcot-Marie-Tooth neuropathy type 2A, and suggest a role for abnormal mitochondrial fusion in the pathogenesis of these human diseases ( 5.1 Fusion and fission processes in mitochondria Mitochondria form a highly dynamic network within the cell through continuous processes of fusion and fission

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Current concepts on the effect of environmental factors on cleft lip and palate