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In the COPD rat model, AICAR upregulated PGC- by activating AMPK- in skeletal muscle, thereby promoting mitochondrial biogenesis and improving skeletal muscle dysfunction in COPD rats ( In addition to the known key factors, SIRT1 and AMPK, that regulate PGC-1, cAMP Response Element-Binding Protein (CREB), an upstream signal, promotes mitochondrial biogenesis by activating PGC-1, which has been verified in bronchial asthma (Wang H

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