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This study was funded in part by the NIH intramural research program and the FDA through an interagency agreement through funds via the Family Smoking Prevention and Tobacco Control Act, as well as by NIH through the NIDCD (HHSN263201300011C and Z1A000046-16), the National Center for Advancing Translational Sciences (UL1TR001105), the National Institute of Mental Health (U01MH104974), the National Institute of Neurological Disorders and Stroke (F31NS093917), and the NIH Office of the Director through the National Institute on Drug Abuse (RC1-DA028710) and the Illuminating the Druggable Genome Common Fund Initiative (U24DK116195)