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[23] These findings lead to the conclusion that the large quantities of free radicals contained in smoke enhance oxidative stress and, in combination with reduced NO bioavailability, nicotine-induced vasoconstriction and impaired vasodilation, may lead to endothelial dysfunction

This packaging design is the first update in five years since 2020

Ensuring that new tobacco products undergo pre-market assessments is a key part of the FDA's efforts to reduce tobacco-related diseases and deaths," said Brian King, director of the FDA's Center for Tobacco Products (CTP) in a press release

These rules apply to all disposable vapes, regardless of whether they contain nicotine or are marketed as nicotine-free