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Once inhaled or swallowed, these fibers: Lodge permanently in the mesothelium lining the lungs or abdomen Trigger chronic inflammation that the body cannot resolve Activate HMGB1 protein a molecular alarm signal that paradoxically promotes cancer cell survival Cause DNA mutations in mesothelial cells over years and decades Switch on oncogenes (c-Myc, c-Jun) that accelerate uncontrolled cell growth Think of asbestos fibers as microscopic splinters your body can never expel