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Here, we provide evidence that PINK1/Parkin-mediated mitophagy is impaired in the hippocampus of AD patients, in induced pluripotent stem cell-derived human AD neurons, and in animal AD models, that impaired removal of defective mitochondria is a pivotal event in AD pathogenesis and that mitophagy represents a potential therapeutic intervention [32]

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Material: 8.0 oz Heavyweight Blend (50/50 Cotton/Poly)

After World War I, cigar holders were no longer used so that shows that this must be an antique piece as well