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Yet another embodiment of the invention, wherein the mainstream cigarette smoke containing very low level of p-BSQ is incapable of producing significant oxidative damage to the lung microsomal proteins of guinea pigs in vivo when the animals are exposed to smoke emitted from the said charcoalfiltered cigarettes in contrast to marked damage of the lung tissue when the animal are exposed to smoke from cigarettes without having the said charcoal filter

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The stimulus intensity range (0.01, 0.1, 1 cd s/m 2 ) was chosen