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Inhalation of nicotine leads first to an increase in vascular tone, and then to a state of chronic spasm, which impairs tissue nutrition and contributes to a more rapid progression of diabetic angiopathy, which in turn worsens blood flow in the lower extremities and may lead to the need for their amputation

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For me, that's up to her, said Adults star Jack Innanen

Surgical Endoscopy, 35, 11831190