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The major limitations of the present study are that we could not use another search engine, for example, EMBASE, due to lack of the access authority, and we could not include the literature published in other languages (not in English) or the data regarding other confounding factors, such as the age, weight, gender, alcohol consumption and how much the participant smoked

First, the bias covariates used, although carefully extracted and evaluated, were based on observable study characteristics and thus may not fully capture unobserved characteristics such as study quality or context, which might be major sources of bias

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