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After a systematic literature search in PubMed (we only considered the metabolites whose serum levels were commonly measured in regular metabolomic studies), we identified several important neurotransmitter-associated metabolites (including tryptophan, tyrosine, phenylalanine, glutamate, glycine) that may closely relate to brain function, especially substance use disorder, which subsequently affect smoking [36,37,38,39]

Comparable regulatory gaps prevail globally, underscoring the urgent need for updated legal frameworks to encompass emerging smokable products

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33 revealed a positive association between current smoking and the waist-to-hip ratio and concluded that smoking enhances abdominal obesity as an unhealthy outcome