In this study, we found that endothelial cells displayed characteristic features of pyroptosis in the aorta of nicotine-treated ApoE / mice fed with HFD, as evidenced by increased levels of caspase-1, IL-1, IL-18, NLRP3, ASC, and TUNEL-positive cells
Exposure to CS promotes various pathophysiology mechanisms like oxidative stress and activation of CYP enzymes 15,16 suppression of CFTR biogenesis 11,29 , ciliophagy and consequently MCC in NHBE cells 11,30
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