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Our results are in line with the findings of previous studies that document the effectiveness of comprehensive tobacco control policies in reducing smoking12 27 28 and larger effects of tobacco control policies (ie, prices) on cigarette smoking in LMICs.3335 While a 10% increase in cigarette prices was estimated to decrease cigarette smoking by 2.50%5%, with an average of 4%, in HICs, a similar increase would reduce cigarette smoking by 2%8%, with an average of 5%, in LMICs.33 Our study is the first to examine the effects of comprehensive cigarette tax policiesmeasured by the Tobacconomics overall cigarette tax scoreson actual smoking behaviours across countries

Thus, accumulation of -ketoglutarate upon CSE treatment might lead to enhanced PHD activation resulting in increased HIF-degradation at least under hypoxia, where hydroxylated HIF-1 was increased by CSE