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Similar results were also identified in lung epithelial cells exposed to various flavor additives such as acetoin (sweet and buttery), orthovanillin (vanilla), and cinnamaldehyde (cinnamon), which exhibited an increase in proinflammatory cytokines synthesis [59]
(The District of Columbia has the highest tax at $4.50 and Missouri has the lowest at 17 cents.) 7-9 All other tobacco products are taxed at 65.08% of the wholesale price.7,8 Clean indoor air ordinances Smoking is prohibited in all government and private workplaces, public schools, restaurants, bars, casinos/gaming establishments (tribal establishments exempt), retail stores, recreational/cultural facilities and childcare facilities.8 E-cigarettes are included in the states clean indoor air law.10 Licensing laws Retailers, wholesalers, and distributors are required to obtain a license to sell tobacco products.7 Retailers, wholesalers, and distributors are required to obtain a license to sell e-cigarette products.10 Youth access laws Effective December 2019, the United States adopted a law raising the federal minimum age of sale of all tobacco products to 21
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