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The GRSs were built on these known smoking-associated SNPs by summing up the additive coding of each SNP weighted by the effect size ascertained from the original study 15

a strong recommendation against their use) because of well-established harms of continued smoking, and some people may be willing to attempt to quit with e-cigarettes but not with other strategies

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In classic tests, carried out by manufacturers with "smoking machines", these micro-perforations let air through and allow for relatively low levels to be obtained, which are reported on cigarette packets