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70 Mutation Q311X in Parkin hinders the degradation of PARIS (Parkin interacting substrate), leading to massive aggregation of PARIS protein, which in turn inhibits the nuclear translocation signal of peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1)-TFEB and impairs mitochondrial degradation
No one else is here to praise or criticize the room note, but maybe you can get away with smoking this around your housemates
doi: 10.1186/s12950-020-00250-8 [DOI] [PMC free article] [PubMed] [Google Scholar] 26.McCubbin A, Fallin-Bennett A, Barnett J, Ashford K
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