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Yes, false negatives can happen in rare cases

Furthermore, continuous squinting and lip pursing, an act frequently done by smokers, can be the cause of fine lines and wrinkles around your face

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However, it also causes cancer in other areas of the body, including: Mouth cancer Throat cancer Larynx cancer Esophagus cancer Bladder cancer Bowel cancer Cervix cancer Kidney cancer Liver cancer Stomach cancer Pancreas cancer In addition, smoking increases your risk of developing problems with your blood flow and other conditions such as: Coronary heart disease Heart attack Stroke Cerebrovascular disease Peripheral vascular disease As for non-smokers, second-hand smoke carries the same increased risk of cancer