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[213] Possible reasons for this phenomenon include nicotine's ability to increase energy metabolism or nicotine's effect on peripheral neurons

[53] The majority of toxic chemicals found in e-cigarette vapor are below 1% of the corresponding levels permissible by workplace exposure standards, [78] but the threshold limit values for workplace exposure standards are generally much higher than levels considered satisfactory for outdoor air quality

Many dozens of film and TV appearances solidified his reputation, including Chariots of Fire (1981), V for Vendetta (2005), and Sherlock Holmes: A Game of Shadows (2011)