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For example, diammonium phosphate reacts with sugars in the slurry process to form favorable flavor precursor compounds like deoxyfructazines [1516], drastically reducing the amount of free ammonia available to transfer to the smoke

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The Four Key Caffeine-Nicotine Interactions Interaction 1 Dopamine Synergy Combined effect is greater than additive When caffeine blocks adenosine receptors at the same time that nicotine activates dopamine release, the combined dopaminergic effect is greater than either substance alone