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3 The US 2009 Family Smoking Prevention and Tobacco Control Act (The Tobacco Control Act) defines a characterizing flavor as any constituent (including a smoke constituent) or additive, an artificial or natural flavor (other than tobacco or menthol) or an herb or spice, including strawberry, grape, orange, clove, cinnamon, pineapple, vanilla, coconut, licorice, cocoa, chocolate, cherry, or coffee, that is a characterizing flavor of the tobacco product or tobacco smoke. 3 As a result of The Tobacco Control Act and increased prevalence of adolescent use of non-tobacco flavored e-cigarettes, many US states (e.g., New Jersey, New York, Rhode Island) and localities have enacted restrictions on the sale of all or some flavored e-cigarettes, with many more states/localities considering restrictions specific to e-cigarettes, e-cigarettes flavors, and other flavored tobacco products
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TREM-1 aggravates chronic obstructive pulmonary disease development via activation NLRP3 inflammasome-mediated pyroptosis
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