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When tobacco is burnt, it creates a toxic smoke and tar is a part of this noxious cloud made of benzene, arsenic and formaldehyde alongside other chemicals

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122 proposed that the link of HCC initiation (differentiated hepatocytes converted into HcPC) and MDM2p53 axis dysfunction is provided by CD44, which is a hyaluronic acid receptor whose expression is rapidly induced in carcinogen-exposed hepatocytes in a STAT3-dependent manner

Data analyses Sample exclusions Of the 285 current adult daily smokers, 7 were excluded from the analysis either because they did not provide a saliva specimen or that cotinine determination was not possible (i.e., insufficient sample)